Which prefix signifies "around" or "surrounding"?

The prefix that signifies "around" or "surrounding" is "peri-." This prefix originates from the Greek word "peri," which means surrounding or enclosing. In medical terminology, "peri-" is commonly used in terms such as "pericardium," which refers to the membrane surrounding the heart, and "periosteum," the connective tissue surrounding the surface of bones. This contextual application underscores the prefix's meaning related to encircling or being around something.

In contrast, the other prefixes have distinct meanings: "inter-" indicates "between" or "among," as in "intercellular," referring to the space between cells. "Intra-" means "within," evident in terms like "intravenous," which describes something located within or administered into a vein. "Sub-" refers to "under" or "below," as seen in "subcutaneous," which pertains to the layer beneath the skin. Each of these prefixes serves a unique purpose in medical terminology, clearly distinguishing them from "peri-," which specifically conveys the idea of being around or surrounding an object.