What is the meaning of the suffix "-sclerosis"?

The suffix "-sclerosis" is derived from the Greek word "skleros," which means hard. When this suffix is used in medical terminology, it specifically indicates a hardening of a tissue or organ. This hardening can occur due to various factors, such as chronic inflammation, disease processes, or the accumulation of certain materials in the body. A well-known example is "arteriosclerosis," which refers to the hardening and thickening of the arterial walls, often associated with aging or disease.

The other options do not align with the definition of the suffix "-sclerosis." For instance, softening indicates a reduction in hardness, inflammation refers to a response of body tissues to injury or infection, and growth implies an increase in size or number, none of which relate to the concept of hardening.